Modern enterprise applications consider cloud-hosted relational databases like Oracle Cloud Database and Amazon RDS PostgreSQL as pivotal components. However, their tuning performance differs greatly because of the optimizer behavior, indexing schemes, and resource management layers. This article provides a thorough analysis comparing the corpus and performance of advanced query optimization techniques in the two platforms under OLTP and OLAP workloads. In a controlled experimental setting with synthetic benchmarks, we found that executing plan hints and parallel query execution with PostgreSQL and Oracle reduced their latency by 47% and 39%, respectively. Moreover, tuned adaptive caching configurations increased the hit ratios by 21% and 18%, respectively. The experiments further indicated that under analytical loads, Postgres showed better cost-per-query efficiency, while Oracle exhibited more predictable scalable performance under high-concurrency workloads. Such fine-grained postulates enable the automation of tuning autovacuum thresholds, JIT compilation switches, and burst I/O behaviors, providing playbooks for workload optimization, creating reference models of cost versus performance which can be used practically by engineers and architects responsible for large, latency constrained systems.